Flunarizine EP Impurity C HCl CAS 90830-31-2(free base)
| CAS No. | 90830-31-2(free base) |
| Molecular Formula | C26H26F2N2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Flunarizine EP Impurity C HCl (CAS 90830-31-2(free base), C26H26F2N2HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Flunarizine EP Impurity C HCl (C26H26F2N2HCl) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 13.0, corresponding to approximately 13 ring(s) or double-bond equivalent(s). With a molecular weight of 440.96 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C26H26F2N2 HCl |
| Molecular Weight | 440.96 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Flunarizine Standards
- Flunarizine impurity 43 (CAS 1133842-25-7)
- Flunarizine Impurity 59 (CAS 114312-65-1)
- Flunarizine impurity 57 (CAS 114374-24-2)
- Flunarizine Impurity N1 (CAS 123375-94-0)
- Flunarizine Impurity N1 HCl (CAS 123375-94-0(free base))
- Flunarizine impurity 46 (CAS 1368426-98-5(free base))
- Flunarizine Impurity 32 (CAS 141528-78-1)
- Flunarizine Impurity 26 (CAS 144917-53-3)
Recommended Standards
- LCZ-696 Impurity 46 (CAS CATO-C4X-169646)
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- Mirtazapine Impurity 24 (CAS CATO-C4X-151124)
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- 2-Ethoxyacetimidamide hydrochloride (CAS 1263377-63-4)
- 3-Cyclopropoxy-5-iodopicolinonitrile (CAS 1243467-74-4)
- (1S,4R,5S,6R)-5-nitro-6-phenylbicyclo[2.2.1]Hept-2-ene (CAS 17197-97-6)
- tert-Butyl ((5-chloro-4-oxo-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydrophthalazin-1-yl)methyl)carbamate (CAS 2836224-64-5)
- Ethyl 2-((2-(3-chloro-4-ethoxyphenyl)pyrazolo[1,5-a]pyrazin-4-yl)thio)acetate (CAS 1105240-36-5)
- Neuropeptide AF (human) (CAS 192387-38-5)
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